Friday, September 11, 2009

ADAR1 and ADAR2

Adar is a Hebrew month.

It figures in the calculation of the leap year of the Jewish calendar system.

Purim holiday falls in that month.

There's an Adar I and an Adar II.

But do you know the difference between ADAR1-S and ADAR1-L ?

No.

Well, according to this:

Mammalian cells express small and large forms of the RNA editing enzyme ADAR1, referred to as ADAR1-S and ADAR1-L, respectively.
Is that complicated?

Well, it was to me. So, try this:

The ADAR (adenosine deaminase that act on RNA) family of RNA-editing enzymes catalyzes the deamination of adenosine to inosine in perfect and imperfect duplex RNA. This family includes two members, ADAR1 and ADAR2, that have been shown to be catalytically active...When editing of these transcripts occurs within coding sequence, the resulting mRNA expresses a different form of the protein from that which is genomically encoded. Hence, selective A-to-I editing serves as a means for generating protein diversity.

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